Synthesis and antimicrobial activity of some new sulfathiazole derivatives

Diazotization of 3,5-diaminopyrazole derivative 2 to form diazonium salt 3, which reacted with either 2-cyano-N-phenylacetamide (4) or  3,5-dimethyl phenol (6) to afford pyrazolo-4,5diazenyl derivatives 5 and 7, respectively. Also, compound 1 was reacted with methyl iodide in potassium carbonate to give N-methyl-N-(4-(N-(thiazol-2-yl)sulfamoyl)phenyl)carbonohydrazonoyl dicyanide (8), which was treated with hydrazine hydrate to give α-cyanoarylhydrazones 9. Moreover, the reaction of compound 1 with either thiourea or hydroxylamine hydrochloride afforded 4-(2-(4,6-diamino-2-thioxopyrimidin-5(2H)-ylidene)hydrazineyl)-N-(thiazol-2-yl)benzenesulfonamide(10)and4-(2-(3-amino-5-iminoisoxazol-4(5H)-ylidene)hydrazineyl)-N-(thiazol-2-yl)benzenesulfonamide (11), respectively. The newly prepared compounds were selected for their biological evaluation as antimicrobial activities