Treatment of 4-((3,5-diamino-1H-pyrazol-4-yl)diazenyl)-N-(thiazol-2-yl)benzenesulfonamide (1) with malononitrile, 2-(ethoxymethylene)malononitrile, ethyl 2-cyano-3-ethoxyacrylate and diethyl 2-(ethoxymethylene)malonate afforded pyrazolo[1,5-a]pyrimidine derivatives 2-5. Also, compound 1 was react with ethyl 3,5-diphenylcyclohexanone-2-acetate (6) afford pyrazolo[5,1-b]quinazoline derivative 7. Moreover, the reaction of aminopyrazole 1 with enaminones 8, 10 in glacial acetic acid gave pyrazolo[1,5-a]pyrimidine derivative 9 and pyrazolo[1,5-a]quinazoline derivative 11. Furthermore, the reaction of aminopyrazole 1 with enaminonitriles 12, 14 gave pyrazolo[1,5-a]pyrimidinederivatives 13 and 15, respectively. The newly prepared compounds were screened for their biological evaluation as antimicrobial activities.
(2019). synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus. Mansoura Journal of Chemistry, 46(4), 16-21. doi: 10.21608/mjcc.2019.413046
MLA
. "synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus", Mansoura Journal of Chemistry, 46, 4, 2019, 16-21. doi: 10.21608/mjcc.2019.413046
HARVARD
(2019). 'synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus', Mansoura Journal of Chemistry, 46(4), pp. 16-21. doi: 10.21608/mjcc.2019.413046
VANCOUVER
synthesis and antimicrobial evaluation of some new pyrazolo[1,5-a]pyrimidine and pyrazolo[1,5-a]quinazoline derivatives bearing sulfathiazole nucleus. Mansoura Journal of Chemistry, 2019; 46(4): 16-21. doi: 10.21608/mjcc.2019.413046
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